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The crash happened between Exit: I-76 turnpike/PA 272 – PA Turnpike/Denver and Exit: US 322 – Blue Ball, according to PennDOT.
The East Cocalico Township police were called to the crash on 222 South in the area of mile marker 43.2, according to a release by the department.
Upon arrival, officers found a commercial truck was stopped on the right shoulder and a Hyundai sedan was on the left shoulder of the highway.
"Initial investigation revealed the sedan struck the rear of the stopped truck," police say.
Two people had been ejected— one of which died at the scene— the other was a woman who was taken to Lancaster General Hospital where she two succumbed to her injuries, according to the release.
A baby was supposedly one of the victims killed in the crash, according to 830AM WEEU talk radio citing dispatchers, although Daily Voice has been unable to independently confirm this.
A third person was hurt and was also taken to Lancaster General Hospital, according to the police release.
"The driver of the commercial truck was uninjured," police say.
Rubbernecking initially caused additional delays, according to PennDOT.
Route 222 was closed from Route 568 to Route 322 at the Ephrata/East Cocalico Township, around 4 p.m. and heavy traffic was reported on Route 272 due to the detour.
"The investigation is ongoing and (the) release of the names of individuals involved (is) pending notification of next of kin," police say.
Anyone who may have witnessed this deadly crash is asked to contact Corporal Steve Walsh of the East Cocalico Township Police Department by calling 717-336-1725.
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